Home Superoksiidi dismutase aktiivsus suhkurtõve korral


Superoksiidi dismutase aktiivsus suhkurtõve korral


An enzyme which catalyzes the dismutation of superoxide radicals (O 2 ·-+ O 2 ·-+ 2H + → O 2 + H 2 O 2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, called superoxide dismutase, contains 2 eq of copper per mole of enzyme. The copper may be reversibly removed, and it is required for activity.



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Superoxide dismutase supplements have not been shown to confer any health benefits. Superoxide dismutase (SOD) is an enzyme found in all cells of the human body. It breaks down superoxide radicals, which are toxic to living cells and cause DNA mutations, into harmless components consisting of oxygen and hydrogen peroxide.

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Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O 2 −) radical into either ordinary molecular oxygen (O 2) or hydrogen peroxide (H 2 O 2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage.
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superoxide dismutase could be differentiated from cyanidc-insen- sitive superoxide dismutase on polyacrylamide elcctrophoreto- grams, by including 1 x 10e3 M cyanide in the developing rea- gents to suppress the activity of the sensitive enzyme. Elcctro- phoresis in acid urea gels was performed as described by Panyim.
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Superoxide dismutase from horseradish has been used in a study to assess the correlation between CuZn superoxide dismutase and glutathione reductase, and environmental and xenobiotic stress tolerance in maize inbreds.
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The mechanism for the toxic superoxide radical disproportionation to molecular oxygen and hydrogen peroxide by copper−zinc superoxide dismutase (CuZnSOD) has been studied using the B3LYP hybrid density functional.
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Superoxide dismutase definition is - a metal-containing antioxidant enzyme that reduces harmful free radicals of oxygen formed during normal metabolic cell processes to oxygen and hydrogen peroxide.




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